ETHICS AND THE MARKETING AUTHORIZATION OF PHARMACEUTICALS: WHAT HAPPENS TO ETHICAL ISSUES DISCOVERED POST-TRIAL AND PRE-MARKETING AUTHORIZATION?

Ethics and the marketing authorization of pharmaceuticals: what happens to ethical issues discovered post-trial and pre-marketing authorization?

Abstract Background In the EU, clinical assessors, rapporteurs and the Committee for Medicinal Products for Human Use are obliged to assess the ethical aspects of a clinical development program and include major ethical flaws in the marketing authorization deliberation processes.To this date, we know very little about the manner that these regulato

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Genome-Wide Association Studies Reveal Neurological Genes for Dog Herding, Predation, Temperament, and Trainability Traits

Genome-wide association study (GWAS) using dog breed standard values as phenotypic measurements is an efficient way to identify genes associated with morphological and behavioral traits.As a result of strong human purposeful selections, several specialized behavioral traits such as herding and hunting have been formed in different modern GENMAI MIS

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Adaptive Triplet Model for Fine-Grained Visual Categorization

Fine-grained visual categorization aims at differentiating subcategories, such as different species of birds, models of cars, and variants of aircraft.It often suffers from small inter-variance and large intra-variance.To keep dissimilar images far apart and preserve large intra-variance simultaneously, we propose an adaptive triplet model.At first

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Structural and Chemical Adaptations of Artemisia monosperma Delile and Limbarda crithmoides (L.) Dumort. in Response to Arid Coastal Environments along the Mediterranean Coast of Egypt

Arid coastal habitats are stressful regions subjected to the effects of biotic and abiotic factors.Vascular plants in these habitats display different responses to cope with these environmental fluctuations.This work addressed the morpho-anatomical features and chemical responses of two medicinal vascular plant species Artemisia monosperma Delile a

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